Authored by
Sanchita Hati headshot
Title

Sanchita Hati, Ph.D.

Pronouns
she/her/hers
Placeholder for titles
Professor
Content type
College of Arts and Sciences
Chemistry and Biochemistry Department

Contact Information

Office
Phillips Hall 445
101 Roosevelt Avenue
Eau Claire, WI 54701
Phone
715-836-3850
Email
ID
Curriculum Vitae Google Scholar
Education

Education

  • Ph.D. in Chemistry, Indian Association for the Cultivation of Science, Jadavpur, India, 1997 
  • M.S. in Chemistry, University of Burdwan, India, 1991 
  • B.S. in Chemistry (Honors), Raj College, University of Burdwan, India, 1989 
Teaching and Research Interests

Teaching and Research Interests

  • Biochemistry and Biophysical Chemistry   

My current research interests focus on the following two areas:

  • Enzymology: Experimental and computational studies of protein structure, dynamics, and function in intercellular-like environments  
  • Spectroscopy: Application of spectroscopic techniques in disease diagnosis and monitoring 
Published Research

Published Research

Publications in the past five years (‘*’ designates undergraduate students):

  1. Shult, C.*, Gunderson, K.*, Coffey, S. J.*, McNally, B.*, Brandt, M.*, Smith, L.*, Steczynski, J.*, Olerich, E. R.*, Schroeder, S. E.*, Severson, N. J.*, Hati, S. and Bhattacharyya, S. "Conformational Fluidity of Intrinsically Disordered Proteins in Crowded Environment: A Molecular Dynamics Simulation Study." J. Biomol. Struct. Dyn. (2024) 1-13; DOI: 10.1080/07391102.2024.2404531.
  2. Liebau, J.*, Laatsch, B. F.*, Rusnak, J.*, Gunderson, K.*, Finke, B.*, Bargender, K.*, Narkiewicz-Jodko, A.*, Weeks, K.*, Williams, M. T.*, Shulgina, I.*, Musier-Forsyth, K., Bhattacharyya, S., and Hati, S. "Polyethylene Glycol Impacts Conformation and Dynamics of Escherichia coli Prolyl-tRNA Synthetase via Crowding and Confinement Effects." Biochemistry (2024) 63, 1621-1635; https://doi.org/10.1021/acs.biochem.3c00719.
  3. S. Hati and S. Bhattacharyya. "Writing a Literature Review as a Class Project in an Upper-Level Undergraduate Biochemistry Course." Biochem. Mol. Biol. Educ. (2024) https://doi.org/10.1002/bmb.21814.
  4. Fossum, C. J.*, Johnson, B. O. V. *, Golde, S. T. *, Kielman, A. J. *, Finke, B. *, Smith, M. A. *, Lowater, H. R. *, Laatsch, B. F. *, Bhattacharyya, S., and Hati, S. “Insight into the Mechanism of Tryptophan Fluorescence Quenching due to Synthetic Crowding Agents: A Combined Experimental and Computational Study.” ACS Omega (2023) 8, 44820–44830; https://doi.org/10.1021/acsomega.3c06006.
  5. Laatsch, B. F. *, Brandt, M. *, Finke, B. *, Fossum, C. J. *, Wackett, M. J. *, Lowater, H. R. *, Narkiewicz-Jodko, A. *, Le, C. N. *, Yang, T., Glogowski, E. M., Bailey-Hartsel, S. C., Bhattacharyya, S., & Hati, S. "Polyethylene Glycol 20k. Does It Fluoresce?" ACS Omega (2023) 8, 14208–14218; https://doi.org/10.1021/acsomega.3c01124. 
  6. Wozney, A. J.*, Smith, M. A.*, Abdrabbo, M.*, Birch, C. M.*, Cicigoi, K. A.*, Dolan, C. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, O'Reilly, M. G.*, Reynolds, J. H.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wwiss, M. M.*, Hati, S. and Bhattacharyya, S., “Evolution of Stronger SARS-CoV-2 Variants as Revealed Through the Lens of Molecular Dynamics Simulations.” Protein J. (2022) 41, 444-456; https://doi.org/10.1007/s10930-022-10065-6. 
  7. Fossum, C. J.*, Laatsch, B. F.*, Lowater, H. R.* Narkiewicz-Jodko*, A. R.*, Lonzarich, L.*, Hati S. and Bhattacharyya, S. “Pre-existing Oxidative Stress Creates a Docking-Ready Conformation of the SARS-CoV-2 Receptor Binding Domain.” ACS Bio. & Med. Chem. Au (2022) 2, 84–93; https://doi.org/10.1021/acsbiomedchemau.1c00040. 
  8. Abdrabbo, M.*, Birch, C. M.*, Brandt, M., K. A.*, Coffey, S. J.*, Dolan, C. C.*, Dvorak, H.*, Gehrke, A. C.*, Gerzema, A. E. L.*, Hansen, A.*, Henseler, E. J.*, Huelsbeck, A. C.*, LaBerge, B.*, Leavens, C. M.*, Le, C. N.*, Lindquist, A. C.*, Ludwig, R. K.*, Reynolds, J. H.*, Severson, N. J.*, Sherman, B. A.*, Sillman, H. W.*, Smith, M. A.*, Smith, M. A.*, Snortheim, M. J.*, Svaren, L. M.*, Vanderpas, E. C.*, Wackett, M. J.*, Wozney, A. J.*, Bhattacharyya, S., and Hati, S. “Vitamin D and COVID-19: A Review on the Role of Vitamin D in Preventing and Reducing the Severity of COVID-19 Infection.” Protein Science  (2021)30 , 2206-2220;  https://doi.org/10.1002/pro.4190.
  9. Hu, Q. H.*; Williams, M. T.*; Shulgina, I.*; Fossum, C.*; Weeks, K.*; Adams, L.A.*; Reinhardt, C. R.*; Musier-Forsyth K.; Hati, S. †; and Bhattacharyya, S. “Editing Domain Motions Preorganize the Synthetic Active Site of Prolyl-tRNA Synthetase.” ACS Catal. (2020) 10, 10229-10242;  https://doi.org/10.1021/acscatal.0c02381.
  10. Zajac, J.*; Anderson, H.*; Adams, L. A.*; Wangmo, D.*; Suhail, S.*; Almen, A.*; Berns, L.*; Coerber, B.*; Dawson, L.*; Hunger, A.*; Jehn, J.*; Johnson, J.*; Plack, N.*; Strasser, S.*; Williams, M. T.*; Bhattacharyya, S.; and Hati, S.  “Effects of Distal Mutations on Prolyl-adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase.” Protein J. (2020) 39, 542-553; https://doi.org/10.1007/s10930-020-09910-3. 
  11. Suhail, S.*; Zajac, Z.*; Fossum, C.*; Lowater, H.*; McCracken, C.*; Severson, N.*; Laatsch, B.*; Narkiewicz-Jodko, A.*; Johnson, B.*; Liebau, J.*; Bhattacharyya, S.; and Hati, S.“Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.” Protein J. (2020) 39, 644-656; https://doi.org/10.1007/s10930-020-09935-8.
  12. Hati S. and Bhattacharyya, S. “Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin Converting Enzyme 2 Receptor.” ACS Omega (2020) 5, 16292-16298; https://doi.org/10.1021/acsomega.0c02125.   
Honors And Recognition

Honors And Recognition

  • Career Excellence in Mentoring, Research, Scholarship, and Creative Activity Award, 2023, UW-Eau Claire
  • Faculty Excellence in Scholarship Award, 2021, UW-Eau Claire
  • University Merit Award, 2017, UW-Eau Claire
  • Recognized as High Demand Faculty, 2009, UW-Eau Claire
  • Lectureship and Research Fellowship Award in Chemistry, University Grant Commission, India